EXPERIMENTAL HEROIN-INDUCED MYOPATHY - ULTRASTRUCTURAL OBSERVATIONS

Authors
PENA J LUQUE E ARANDA C JIMENA I VAAMONDE R
Citation
J. Pena et al., EXPERIMENTAL HEROIN-INDUCED MYOPATHY - ULTRASTRUCTURAL OBSERVATIONS, Journal of submicroscopic cytology and pathology, 25(2), 1993, pp. 279-284
Citations number
13
Categorie Soggetti
Cytology & Histology",Pathology
Journal title
Journal of submicroscopic cytology and pathology → ACNP
ISSN journal
11229497
Volume
25
Issue
2
Year of publication
1993
Pages
279 - 284
Database
ISI
SICI code
1122-9497(1993)25:2<279:EHM-UO>2.0.ZU;2-7
Abstract
Electron microscopic analysis was used to study the ultrastructural ch anges taking place in rat soleus muscle following intraperitoneal admi nistration of pure heroin. Degenerative changes observed consisted pri marily of hypercontracted fibers at different stages of development. E vidence of regeneration was also found. Results show the myotoxic effe ct of pure heroin on skeletal muscle. The pathogenesis of muscle damag e is discussed.