TOTAL, LDL AND VLDL CHOLESTEROL, TRIGLYCERIDES AND PHOSPHOLIPIDS IN THE SERUM OF GUINEA-PIGS WITH EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

Total, LDL and VLDL lipids - cholesterol, triglycerides and phopholipi ds were determined in the serum of guinea pigs with experimental aller gic encephalomyelitis (EAE). EAE was induced by immunization with myel in basic protein (MBP) and galactocerebroside (GC). The results showed no differences in the total cholesterol, triglycerides and phospholip ids. The content of these lipids was increased in the LDL fraction of lipoproteins (LP) and decreased in the VLDL fraction. A possible expla nation is absorption of the break-down products of myelin lipid degrad ation by increased activity of lipolytic enzymes and rapid conversion of plasma high density lipoproteins (HDL) to very low density lipoprot eins (VLDL) and low density lipoproteins (LDL) in the serum of guinea pils in EAE. The lipoprotein lipids of myelin possible have a role in the processes of demyelination in the immune reaction in EAE.