SYNTHESIS OF A SITE-SPECIFIC DEUTERIUM SUBSTITUTED METHYL BETA-D-GLUCAN DECASACCHARIDE

Synthesis of a beta-D-glucan decasaccharide, with alternating beta-1,3 and beta-1,4-linkages, is described. The decasaccharide is fully C-de uterated except for the central cellobiose residue. The main glycosyla tion methods used were activation of glycosyl bromides with silver tri flate or activation of thioglycosides with dimethyl(methylthio)sulfoni um triflate (DMTST). In order to establish the anomeric configuration of the various oligosaccharide derivatives, a fully C-protonated decas accharide was also synthesized by a parallel route.