LIPOPROTEIN(A) CONCENTRATION SHOWS LITTLE RELATIONSHIP TO IDDM COMPLICATIONS IN THE PITTSBURGH EPIDEMIOLOGY OF DIABETES COMPLICATIONS STUDYCOHORT

OBJECTIVE - To examine the potential associations of lipoprotein(a) an d the complications of IDDM and their risk factors. RESEARCH DESIGN AN D METHODS - This report focuses on 186 individuals with IDDM (mean age = 34 yr) participating in a 10-yr prospective study examining various complications. Lp(a) concentrations were evaluated for those with and without complications. RESULTS - A weak correlation was seen between Lp(a) and HbA, (r = 0.16, P < 0.05). Lp(a) concentrations were not sig nificantly different for those with or without proliferative retinopat hy, overt nephropathy, peripheral vascular disease, or definite myocar dial infarction or angina. However, an inverse association (P < 0.05) was seen with distal symmetric polyneuropathy. These results were also confirmed by categorical analyses (i.e., Lp(a) levels less-than-or-eq ual-to 30 vs. > 30 mg/dl). CONCLUSIONS - These results suggest that an y association of Lp(a) concentration with IDDM complications is likely to be weak or nonexistent. However, prospective studies are needed be fore its full role can be determined.