BIOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF 2 FORMS OF PERTACTIN, THE69,000-MOLECULAR-WEIGHT OUTER-MEMBRANE PROTEIN OF BORDETELLA-PERTUSSIS

Authors
GOTTO JW ECKHARDT T REILLY PA SCOTT JV COWELL JL METCALF TN MOUNTZOUROS K GIBBONS JJ SIEGEL M
Citation
Jw. Gotto et al., BIOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF 2 FORMS OF PERTACTIN, THE69,000-MOLECULAR-WEIGHT OUTER-MEMBRANE PROTEIN OF BORDETELLA-PERTUSSIS, Infection and immunity, 61(5), 1993, pp. 2211-2215
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
5
Year of publication
1993
Pages
2211 - 2215
Database
ISI
SICI code
0019-9567(1993)61:5<2211:BAIPO2>2.0.ZU;2-H
Abstract
Two apparent isoforms of the virulence-associated 69,000-molecular-wei ght protein pertactin were purified from Bordetella pertussis. Mass sp ectrometry showed a difference of 2,060 Da, which may result from diff erential C-terminal cleavage of a larger precursor. Both forms were pr otective in a mouse model, eliciting bactericidal antibodies and reduc ing respiratory tract colonization.