ANTIGENIC AND FUNCTIONAL DIFFERENCES IN ADHESION OF PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES TO HUMAN AND BOVINE CD36

Authors
OCKENHOUSE CF TANDON NN JAMIESON GA GREENWALT DE
Citation
Cf. Ockenhouse et al., ANTIGENIC AND FUNCTIONAL DIFFERENCES IN ADHESION OF PLASMODIUM-FALCIPARUM-INFECTED ERYTHROCYTES TO HUMAN AND BOVINE CD36, Infection and immunity, 61(5), 1993, pp. 2229-2232
Citations number
27
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
61
Issue
5
Year of publication
1993
Pages
2229 - 2232
Database
ISI
SICI code
0019-9567(1993)61:5<2229:AAFDIA>2.0.ZU;2-S
Abstract
Cytoadherence by Plasmodium falciparum-infected erythrocytes (PRBC) to microvascular endothelium is, in part, mediated by the specific inter action between a parasite-derived erythrocyte surface ligand and a spe cific binding site on human CD36. We describe the selection for increa sed adhesion of PRBC to bovine CD36 and demonstrate that the molecular interaction between PRBC and bovine CD36 is independent of and distin ct from the OKM5/8 monoclonal antibody epitopes which block PRBC-human CD36 binding.