BILATERAL REORGANIZATION OF MOSSY FIBERS IN THE RAT HIPPOCAMPUS AFTERA UNILATERAL INTRACEREBROVENTRICULAR KAINIC ACID INJECTION

One month after a unilateral intracerebroventricular injection of the neurotoxin kainic acid (KA) a prominent band of zinc-containing Timm's -stained terminals is present in the inner molecular layer of the ipsi lateral dentate gyrus. At 3 months, mossy fibre reorganisation is also seen in the contralateral inner molecular layer of the dentate gyrus and in the infrapyiramidal band in the contralateral CA3. The relation ship of this reactive plasticity to the CA3 lesion is discussed.