In this paper we study the inviscid instability of a skewed compressib
le mixing layer between streams of different velocity magnitude and di
rection. The mean flow is governed by the three-dimensional laminar bo
undary-layer equations and can be reduced to a sum of a uniform flow a
nd a two-dimensional shear flow. In the stability analysis, the amplif
ication direction is assumed to be normal to the homogeneous direction
of the mean flow. The results show that skewing enhances the instabil
ity by a factor of three for the incompressible mixing layer with velo
city ratio 0.5 and uniform temperature. Under compressible conditions,
skewing still increases the maximum amplification rate for a medium c
onvective Mach number, but the enhancement is smaller. A scaling of th
e skewing effect is introduced which quantitatively explains the linea
r stability behaviour. Similarly, a suitably defined convective Mach n
umber explains the compressibility effect.