2'-SUBSTITUTED AND 3'-SUBSTITUTED SANGIVAMYCINS - CONFORMATIONAL RESTRICTION BY THE GAUCHE EFFECT

Authors
IIMORI T MURAI Y WAKIZAKA Y OHTSUKA Y OHUCHI S KODAMA Y OISHI T
Citation
T. Iimori et al., 2'-SUBSTITUTED AND 3'-SUBSTITUTED SANGIVAMYCINS - CONFORMATIONAL RESTRICTION BY THE GAUCHE EFFECT, Chemical and Pharmaceutical Bulletin, 41(4), 1993, pp. 775-777
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
41
Issue
4
Year of publication
1993
Pages
775 - 777
Database
ISI
SICI code
0009-2363(1993)41:4<775:2A3S-C>2.0.ZU;2-H
Abstract
Conformational restrictions of sangivamycin (1) could be achieved by t he use of the gauche effect of the substituents on the ribofuranose mo iety. The conformational deviations obtained by this method were found to nicely correlate with the inhibitory activity of PKC.