U. Sivagnanam et al., SYNTHESIS OF CERTAIN MULTIDENTATE BENZIMIDAZOLE-DERIVED LIGANDS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 32(5), 1993, pp. 572-576
Synthetic procedures are described for obtaining various multidentate
ligands incorporating benzimidazole moieties. The benzimidazoles were
obtained by the condensation of acids with o-phenylenediamines. Synthe
ses are reported for N,N-bis (1-methylbenzimidazol-2-ylmethyl)amine (2
), N,N'-bis (1-methylbenzimidazol-2-ylethyl)ethylenediamine (5), N,N,N
',N'- tetrakis (benzimidazol- 2-ytmethyl)- 1,2-diaminocyclohexane (6),
N,N,N',N'-tetrakis hylbenzimidazol-2-ylmethyl)-1,2-diaminocyclohexane
(7), HOOC-(CH2)m-S-CH2-CH2-S-(CH2)n-S- CH2-CH2-S-(CH2)m-COOH [where n
= 2, m = 1(8); n = 2, m = 2 (10); n = 3, m = 1 (12)], BzIm-(CH2m- S-C
H2-CH2-S- (CH2)n-S-CH2-CH2-S-(CH2)m-BzIm [where n = 2, m = 1 (9); n =
2, m = 2 (11); n = 3, m = 1 (13); n = 3, m = 2 (14) and BzIm = benzimi
dazol-2-yl], HOOC-CH2-S-CH2-CH2-S)4- CH2-COOH (15) and BzIm-CH2-S-(CH2
-CH2-S)4-CH2-BzIm (16).