PHARMACOLOGICAL STUDIES ON SMALL PEPTIDE FRACTION DERIVED FROM SOYBEAN - THE EFFECTS OF SMALL PEPTIDE FRACTION DERIVED FROM SOYBEAN ON FATIGUE, OBESITY AND GLYCEMIA IN MICE

The present research was an attempt to determine the pharmacological a ctions as for anti-fatigue, antiobesity and hypoglycemia of small pept ide isolated from soybean in mice. Small peptide administration preven ted the decrease in sporting movement induced by concussion stress for 3 h in mice. In addition, it should be noted that the recovery rate o f fatigue in 60 min after small peptide administration was over one hu ndred percentage in comparison with that after pretreatment, while the equivalent dose administration of amino acid mixture with the same sm all peptide amino acid composition did not prevent the decrease in spo rting movement. In goldthioglucose (500 mg/kg (i.p.))-induced obese mo use body weight gain, liver weight and body lipid level around uterine were significantly reduced by the chronicoral administration of small peptide (200, 1000 mg/kg). Administration in 1000 mg per kg of small peptide significantly lowerd hyperglycemia in 30 and 120 min after glu cose (3 g/kg (p.o.)) administration, whereas the equivalent amino acid mixture showed no effect. In conclusion, it suggested that small pept ide isolated from soybean might have some pharmacological effects of a nti-fatigue, antiobesity, and hypoglycemia.