COMPARISON OF THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE STRUCTURAL PROTEIN GENES OF THE YELLOW-FEVER 17DD VACCINE STRAIN FROM SENEGAL WITH THOSE OF OTHER YELLOW-FEVER VACCINE VIRUSES

Authors
JENNINGS AD WHITBY JE MINOR PD BARRETT ADT
Citation
Ad. Jennings et al., COMPARISON OF THE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE STRUCTURAL PROTEIN GENES OF THE YELLOW-FEVER 17DD VACCINE STRAIN FROM SENEGAL WITH THOSE OF OTHER YELLOW-FEVER VACCINE VIRUSES, Vaccine, 11(6), 1993, pp. 679-681
Citations number
14
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
11
Issue
6
Year of publication
1993
Pages
679 - 681
Database
ISI
SICI code
0264-410X(1993)11:6<679:COTNAD>2.0.ZU;2-5
Abstract
The nucleic acid and deduced amino acid sequences of the structural pr oteins of the 17DD vaccine strain of yellow fever (YF) virus originati ng from Senegal are compared with those published for other vaccine st rains of YF virus. Even though the 17D-204 and 17DD substrains of 17D diverged at passage 195 of 17D, they show a very high degree of nucleo tide (99.5%) and amino acid (99.5%) homology over this region. The seq uences are discussed with respect to monoclonal antibodies that can di stinguish between 17DD and 17D-204 substrains of YF vaccines.