ANTIINFLAMMATORY ACTIVITY OF GLYCOGEN EXTRACTED FROM PERNA-CANALICULUS (NZ GREEN-LIPPED MUSSEL)

Citation
Te. Miller et al., ANTIINFLAMMATORY ACTIVITY OF GLYCOGEN EXTRACTED FROM PERNA-CANALICULUS (NZ GREEN-LIPPED MUSSEL), Agents and actions, 38, 1993, pp. 139-142
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00654299
Volume
38
Year of publication
1993
Pages
139 - 142
Database
ISI
SICI code
0065-4299(1993)38:<139:AAOGEF>2.0.ZU;2-X
Abstract
Previous laboratory based investigations of a commercially prepared fr eeze-dried extract of the NZ green-lipped mussel (Perna canaliculus) s howed that the material had the capacity to inhibit experimentally ind uced inflammation. The activity was thought to reside within an aqueou s fraction containing high molecular weight material, possibly a polys accharide. In the present study, a polysaccharide (glycogen) has been extracted from Perna canaliculus and its anti-inflammatory activity ex amined in an attempt to characterise further the high molecular weight components of this mollusc. Glycogen extracts administered i.v. demon strated a dose-dependent anti-inflammatory effect in rats with carrage enin-induced footpad oedema. Mobilisation of neutrophils to the site o f an inflammatory stimulus was also significantly reduced. This activi ty. was lost if the glycogen extract was treated with KOH or proteinas e K, suggesting that the anti-inflammatory properties resided within a protein moiety associated with the glycogen.