A PRELIMINARY-STUDY OF INVITRO ANTIBIOTIC-ACTIVITY OF SAPERCONAZOLE AND OTHER AZOLES ON PARACOCCIDIOIDES-BRASILIENSIS

Saperconazole, a new triazole related to itraconazole, was tested agai nst Paracoccidioides brasiliensis and results compared with ketoconazo le and itraconazole. The fungus was highly sensitive to the action of these compounds, particularly saperconazole, with minimum inhibitory c oncentrations and minimum fungicidal concentrations ranging from 10(-7 ) to 10(-10) m (equivalent to 6.7 x 10(-2)-6.7 x 10(-5) mug ml-1 for s aperconazole), according to the morphological phase and the antifungal tested. The yeast phase was more sensitive than the mycelial phase to any of the azoles. Morphological changes were observed in the cell me mbranes, particularly when saperconazole was used as the antifungal ag ent.