RAPID DETECTION OF ANEUPLOIDY IN UNCULTURED CHORIONIC VILLUS CELLS USING FLUORESCENCE INSITU HYBRIDIZATION

Authors
RAO PN HAYWORTH R COX K GRASS F PETTENATI MJ
Citation
Pn. Rao et al., RAPID DETECTION OF ANEUPLOIDY IN UNCULTURED CHORIONIC VILLUS CELLS USING FLUORESCENCE INSITU HYBRIDIZATION, Prenatal diagnosis, 13(4), 1993, pp. 233-238
Citations number
15
Categorie Soggetti
Obsetric & Gynecology
Journal title
Prenatal diagnosis → ACNP
ISSN journal
01973851
Volume
13
Issue
4
Year of publication
1993
Pages
233 - 238
Database
ISI
SICI code
0197-3851(1993)13:4<233:RDOAIU>2.0.ZU;2-Y
Abstract
Rapid detection of aneuploidy using chromosome-specific repetitive DNA probes and the potential diagnostic accuracy of fluorescence in situ hybridization (FISH) on interphase cells of chorionic villus samples ( CVS) are presented. Analyses demonstrated the ability to correctly ide ntify aneuploidy using FISH in uncultured CVS. Our preliminary investi gation suggests that this technique offers a significant clinical pote ntial to circumvent problems of culture, time, and cost in cytogenetic analysis.