I. Kennerknecht et al., A PROSPECTIVE CYTOGENETIC STUDY OF 3RD-TRIMESTER PLACENTAE IN SMALL-FOR-DATE BUT OTHERWISE NORMAL NEWBORNS, Prenatal diagnosis, 13(4), 1993, pp. 257-269
Data in the literature suggest that confined placental mosaicism might
be associated with intrauterine growth retardation. However, this ass
ociation may be coincidental and due to bias of ascertainment. We ther
efore started a prospective study based on the cytogenetic evaluation
of placentae derived from growth-retarded newborns. We further minimiz
ed possible bias by excluding those small-for-date infants displaying
findings which already could explain intrauterine growth retardation (
mothers who are smokers, multiple pregnancies, gestosis, dysmorphic in
fants). In a collection of 71 small-for-gestational age newborns, we d
id not see a single case of true confined placental mosaicism.