EVIDENCE OF A 2ND GAMETE FUSION AFTER THE 1ST CLEAVAGE OF THE ZYGOTE IN A 47-XX+18 70-XXX+18-MOSAIC - A REMARKABLE DIPLOID TRIPLOID DISCREPANCY AFTER CVS/

Authors
TUERLINGS JHAM BREED ASPM VOSTERS R ANDERS GJPA
Citation
Jham. Tuerlings et al., EVIDENCE OF A 2ND GAMETE FUSION AFTER THE 1ST CLEAVAGE OF THE ZYGOTE IN A 47-XX+18 70-XXX+18-MOSAIC - A REMARKABLE DIPLOID TRIPLOID DISCREPANCY AFTER CVS/, Prenatal diagnosis, 13(4), 1993, pp. 301-306
Citations number
17
Categorie Soggetti
Obsetric & Gynecology
Journal title
Prenatal diagnosis → ACNP
ISSN journal
01973851
Volume
13
Issue
4
Year of publication
1993
Pages
301 - 306
Database
ISI
SICI code
0197-3851(1993)13:4<301:EOA2GF>2.0.ZU;2-Z
Abstract
A 70,XXX, + 18 karyotype was found by chorionic villus sampling, while the fetal fibroblast culture of the affected fetus revealed a 47,XX, + 18 karyotype. From several possible mechanisms, we assume that a sec ond gamete fusion occurred after the first cell division of the zygote . According to this interpretation, the mosaicism arose in very early pregnancy (at the two-cell stage). This discrepancy can therefore be e xplained by selection pressure, due to the differentiation processes i n the embryonic tissues.