The cytoplasmically inherited M double-stranded (ds) RNA genome segmen
t of killer virus of Saccharomyces cerevisiae is heat-curable in some
yeast strains but not in others. Temperature sensitivity is conferred
on both M1 and M2 dsRNA satellite virus segments by the L-A-HN allele
of the killer helper virus genome, but not by the L-A-H allele. Both d
iploidy and mating type heterozygosity of the host cell are also corre
lated with increased virus curability.