SYNTHESIS OF SOME NEW THIOETHERS OF 1,2,4-TRIAZINE-3-HYDRAZONES AND ASSAYS FOR THEIR ANTICANCER AND ANTIHUMAN IMMUNE VIRUS ACTIVITIES

Authors
ABDELRAHMAN RM SEADA M FAWZY M ELBAZ I
Citation
Rm. Abdelrahman et al., SYNTHESIS OF SOME NEW THIOETHERS OF 1,2,4-TRIAZINE-3-HYDRAZONES AND ASSAYS FOR THEIR ANTICANCER AND ANTIHUMAN IMMUNE VIRUS ACTIVITIES, Il Farmaco, 48(3), 1993, pp. 397-406
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
3
Year of publication
1993
Pages
397 - 406
Database
ISI
SICI code
0014-827X(1993)48:3<397:SOSNTO>2.0.ZU;2-C
Abstract
A number of various thioethers derived from 3-hydrazone-5,6-diphenyl-1 ,2,4-triazines have been synthesized and evaluated for anticancer and anti HIV activities. The structures are supported by elemental analysi s, IR, UV and H-1-NMR spectral data. Most of the tested compounds disp layed a significant activity against Leukemia/Lymphoma, CNS, Ovarian a nd Small cell lung cancer.