ANALYSIS OF CALCIUM-CHANNEL BLOCKING DIHYDROPYRIDINES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

Authors
BARBATO F CAPPELLO B GRUMETTO L MORRICA P
Citation
F. Barbato et al., ANALYSIS OF CALCIUM-CHANNEL BLOCKING DIHYDROPYRIDINES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Il Farmaco, 48(3), 1993, pp. 417-426
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
48
Issue
3
Year of publication
1993
Pages
417 - 426
Database
ISI
SICI code
0014-827X(1993)48:3<417:AOCBDB>2.0.ZU;2-C
Abstract
Nine dihydropyridine calcium blockers have been analyzed by HPLC. Simu ltaneous analysis has been performed both using different isocratic co nditions and linear gradient method. The influence of pH and ionic str ength of the mobile phase on separation mechanism is discussed. Moreov er, the separation ability of original compounds from daylight degrada tion products has been studied.