F. Barbato et al., ANALYSIS OF CALCIUM-CHANNEL BLOCKING DIHYDROPYRIDINES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY, Il Farmaco, 48(3), 1993, pp. 417-426
Nine dihydropyridine calcium blockers have been analyzed by HPLC. Simu
ltaneous analysis has been performed both using different isocratic co
nditions and linear gradient method. The influence of pH and ionic str
ength of the mobile phase on separation mechanism is discussed. Moreov
er, the separation ability of original compounds from daylight degrada
tion products has been studied.