THE CALCULATION AND SYNTHESIS OF A TEMPLATE MOLECULE

Authors
WILSON SR TAM WK DIGRANDI MJ CUI WL
Citation
Sr. Wilson et al., THE CALCULATION AND SYNTHESIS OF A TEMPLATE MOLECULE, Tetrahedron, 49(17), 1993, pp. 3655-3663
Citations number
56
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
17
Year of publication
1993
Pages
3655 - 3663
Database
ISI
SICI code
0040-4020(1993)49:17<3655:TCASOA>2.0.ZU;2-0
Abstract
This paper discusses an algorithm to compute the geometric requirement s for a template molecule. A Program called DESIGN is used to calculat e templates by matching vectors from a database of carbon skeleta. App lications of the approach to an epitope of myoglobin and a fragment ar ound the active site of the enzyme thioredoxin is examined. The synthe sis of the template molecule 7 is described.