TOWARD DEVELOPING PEPTIDOMIMETICS - SUCCESSFUL REPLACEMENT OF BACKBONE AMIDE BONDS IN TETRAPEPTIDE-BASED CCK-A RECEPTOR AGONISTS

Authors
SHIOSAKI K LIN CW LEANNA MR MORTON HE MILLER TR WITTE D STASHKO M NADZAN AM
Citation
K. Shiosaki et al., TOWARD DEVELOPING PEPTIDOMIMETICS - SUCCESSFUL REPLACEMENT OF BACKBONE AMIDE BONDS IN TETRAPEPTIDE-BASED CCK-A RECEPTOR AGONISTS, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 855-860
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
855 - 860
Database
ISI
SICI code
0960-894X(1993)3:5<855:TDP-SR>2.0.ZU;2-W
Abstract
The backbone amide bonds in two series of tetrapeptide-based CCK-A rec eptor agonists were systematically replaced with the methylene amino i sostere. Potent and selective pseudopeptides were identified that will facilitate our understanding of how these peptides interact with the CCK receptor and their structural correlations with other CCK ligands. This information will aid in the eventual development of peptidomimet ics.