DIPHENYLPYRAZOLIDINONE AND BENZODIAZEPINE CHOLECYSTOKININ ANTAGONISTS- A CASE OF CONVERGENT EVOLUTION IN MEDICINAL CHEMISTRY

Authors
HOWBERT JJ LOBB KL BRITTON TC MASON NR BRUNS RF
Citation
Jj. Howbert et al., DIPHENYLPYRAZOLIDINONE AND BENZODIAZEPINE CHOLECYSTOKININ ANTAGONISTS- A CASE OF CONVERGENT EVOLUTION IN MEDICINAL CHEMISTRY, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 875-880
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
875 - 880
Database
ISI
SICI code
0960-894X(1993)3:5<875:DABCA>2.0.ZU;2-4
Abstract
Two recently described classes of nonpeptide cholecystokinin receptor antagonists contain diphenylpyrazolidinone and benzodiazepine substruc tures, respectively. Although the origins and development of these ser ies were completely independent, the low energy conformations predicte d by modeling showed remarkable three-dimensional homology between the structures.