THE PREPARATION OF (PERFLUOROALKYL)IMIDAZOLES AS NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS

Authors
CARINI DJ CHIU AT WONG PC JOHNSON AL WEXLER RR TIMMERMANS PBMWM
Citation
Dj. Carini et al., THE PREPARATION OF (PERFLUOROALKYL)IMIDAZOLES AS NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 895-898
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
895 - 898
Database
ISI
SICI code
0960-894X(1993)3:5<895:TPO(AN>2.0.ZU;2-F
Abstract
A series of (perfluoroalkyl)imidazoles have been prepared and are pote nt angiotensin II antagonists. One of these compounds, DuP 532, l-5-yl )biphenyl-4-yl]methyl]imidazole-5-carboxylic acid, is a selective anta gonist of angiotensin II which causes a marked and long-lasting drop i n blood pressure when administered orally to a renal hypertensive rat.