NUCLEAR VARIATIONS OF QUINUCLIDINE SUBSTANCE-P ANTAGONISTS - 2-DIPHENYLMETHYL-1-AZABICYCLO[3.2.2]NONAN-3-AMINES

Authors
LOWE JA DROZDA SE SNIDER RM LONGO KP RIZZI JP
Citation
Ja. Lowe et al., NUCLEAR VARIATIONS OF QUINUCLIDINE SUBSTANCE-P ANTAGONISTS - 2-DIPHENYLMETHYL-1-AZABICYCLO[3.2.2]NONAN-3-AMINES, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 921-924
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
921 - 924
Database
ISI
SICI code
0960-894X(1993)3:5<921:NVOQSA>2.0.ZU;2-4
Abstract
The synthesis and SAR of a series of I-azabicyclo[3.2.2] analogues of the nonpeptide substance P antagonist CP-96,345 are described. The res ults demonstrate the sensitivity of the substance P receptor toward al terations in the nuclear structure of CP-96,345.