PHARMACOLOGICAL PROFILE AND CHEMICAL SYNTHESIS OF SR-48968, A NONPEPTIDE ANTAGONIST OF THE NEUROKININ-A NK(2) RECEPTOR

Authors
EDMONDSALT X PROIETTO V VANBROECK D VILAIN P ADVENIER C NELIAT G LEFUR G BRELIERE JC
Citation
X. Edmondsalt et al., PHARMACOLOGICAL PROFILE AND CHEMICAL SYNTHESIS OF SR-48968, A NONPEPTIDE ANTAGONIST OF THE NEUROKININ-A NK(2) RECEPTOR, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 925-930
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
925 - 930
Database
ISI
SICI code
0960-894X(1993)3:5<925:PPACSO>2.0.ZU;2-U
Abstract
SR 48968 is a potent, competitive and selective non-peptide antagonist of the neurokinin A (NK2) receptor. The synthesis of SR 48968 is desc ribed. Structure activity relationship is shown using binding and phar macological results.