NOVEL Y2-SELECTIVE, REDUCED-SIZE AGONISTS OF NEUROPEPTIDE-Y

Authors
BECKSICKINGER AG HOFFMANN E GAIDA W GROUZMANN E DURR H JUNG G
Citation
Ag. Becksickinger et al., NOVEL Y2-SELECTIVE, REDUCED-SIZE AGONISTS OF NEUROPEPTIDE-Y, Bioorganic & medicinal chemistry letters, 3(5), 1993, pp. 937-942
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
3
Issue
5
Year of publication
1993
Pages
937 - 942
Database
ISI
SICI code
0960-894X(1993)3:5<937:NYRAON>2.0.ZU;2-X
Abstract
The prerequisite for Y2-mediated biological activity was elaborated by synthesizing analogs of neuropeptide Y (NPY) 1-4-Ahx-25-36. The findi ng, that a pronounced hydrophobic segment is required in the C-termina l segment for signal transduction led to the development of a Y2-selec tive agonist, which contains cyclohexylalanine at position 30 and/or 3 1.