We conducted a case control study to find the extent to which acute vi
rus B hepatitis was hospital acquired. One hundred and sixty consecuti
ve cases of acute virus B hepatitis were compared with age (+/- 3 year
s) and sex matched healthy hospital visitors. Exposure to reusable nee
dles, blood or blood products, therapeutic and diagnostic procedures,
common razors and sexual practices were elicited by means of a questio
nnaire. Only exposures in the incubation period (6 weeks to 6 months b
efore the onset of symptoms) were included in the analysis. The odds r
atio (OR) for injections for reusable needles was 6.3 [95% confidence
interval (CI) = 3.8-10.6]. The OR for single injection (OR = 3.9; 95%
CI = 2.0-7.3) was less than that for multiple injections (OR = 9.8; 95
% CI = 3.8-26.3), showing a dose response relationship. The proportion
of cases of acute virus B hepatitis attributable to hospital related
exposures was 67%. Proper aseptic techniques and sterilization practic
es can substantially reduce the incidence of acute hepatitis B in the
population.