The aim of this study was to search for small bowel lesions by means o
f a perioperative endoscopy in 20 patients operated on for Crohn's dis
ease. Seven women and 13 men (mean age 29 years) had a total retrograd
e exploration to the angle of Treitz during an ileocolectomy (16 of 20
patients) or a colonic or ileal resection (four of 20 patients). Endo
scopic exploration was completed, through an enterotomy, from the surg
ical area to the angle of Treitz. Periendoscopic biopsy samples were t
aken on macroscopic lesions and every 20 cm systematically. In 13 of 2
0 cases, various lesions scattered over the whole small intestine were
found. These were aphthoid ulcerations (10 patients), superficial ulc
erations (seven patients), mucosal oedema (three patients), non-ulcera
tive stenosis (three patients), erythema (two patients), pseudopolyps
(two patients), deep ulcerations (two patients), and ulcerative stenos
is (one patient). In seven patients none of the lesions detected at pe
rioperative endoscopy had been recognised by preoperative evaluation o
r surgical inspection of the serosal surface. A typical granuloma was
found at biopsy of lesions identified by endoscopy in three cases and
at biopsy of an apparently healthy area in one case. Thus 65% of patie
nts operated on for Crohn's disease had lesions of the small intestine
detected by endoscopy, which were unrecognised before surgery in more
than half of the cases.