LOSS OF FUNCTION OF THE DROSOPHILA-ZFH-1 GENE RESULTS IN ABNORMAL-DEVELOPMENT OF MESODERMALLY DERIVED TISSUES

Authors
LAI ZC RUSHTON E BATE M RUBIN GM
Citation
Zc. Lai et al., LOSS OF FUNCTION OF THE DROSOPHILA-ZFH-1 GENE RESULTS IN ABNORMAL-DEVELOPMENT OF MESODERMALLY DERIVED TISSUES, Proceedings of the National Academy of Sciences of the United Statesof America, 90(9), 1993, pp. 4122-4126
Citations number
32
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
9
Year of publication
1993
Pages
4122 - 4126
Database
ISI
SICI code
0027-8424(1993)90:9<4122:LOFOTD>2.0.ZU;2-2
Abstract
The Drosophila zfh-1 gene encodes an unusual protein with nine Cys2His 2 type zinc-ringer motifs and one homeodomain that shows a complex pat tern of expression in the embryonic mesoderm and nervous system. To st udy the function of zfh-1, we generated loss-of-function zfh-1 mutatio ns. Phenotypic analysis of zfh-1 mutant embryos reveals that the gene is not required for the initial segregation of the mesoderm or for the differentiation of mesodermally derived tissues. Rather, loss of zfh- 1 function results in various degrees of local errors in cell fate or positioning.