EFFECT OF SUCRALFATE AND BASIC FIBROBLAST GROWTH-FACTOR ON FIBROVASCULAR INGROWTH INTO HYDROXYAPATITE AND POROUS POLYETHYLENE ALLOPLASTIC IMPLANTS USING A NOVEL RABBIT MODEL
Pad. Rubin et al., EFFECT OF SUCRALFATE AND BASIC FIBROBLAST GROWTH-FACTOR ON FIBROVASCULAR INGROWTH INTO HYDROXYAPATITE AND POROUS POLYETHYLENE ALLOPLASTIC IMPLANTS USING A NOVEL RABBIT MODEL, Ophthalmic plastic and reconstructive surgery, 13(1), 1997, pp. 8-17
This study investigated the effects of sucralfate and basic fibroblast
growth factor (bFGF) on fibrovascular ingrowth into porous implant ma
terials. Seven white female New Zealand rabbits underwent bilateral ab
dominal incisions through which porous orbital spherical or and disc-s
haped implants were inserted between their abdominal muscles. Eighty h
ydroxyapatite (HA) and porous polyethylene (PP) implants, each materia
l of different pore sizes, were implanted. These implants were either
uncoated or coated with suspensions of polyhydroxymethylmethacrylate (
hydron); hydron and sucralfate; or hydron, sucralfate, and bFGF. Impla
nts were harvested after 1, 3, or 6 weeks. Observers classified the ex
tent of fibrovascular ingrowth in a blind manner using light microscop
y. All discs and spheres showed fibrovascular ingrowth; at 6 weeks, al
most all implants were fully vascularized. Although demonstrating diff
erent degrees of fibrovascular maturity, all 3- and 6-week discs showe
d complete cellular ingrowth. Overall, the most extensive and mature f
ibrovascularization was found in HA implants, regardless of shape, dur
ation of implantation, or angiogenic enhancing agent used. Thus, this
study indicates that fibrovascular ingrowth into porous implants is mo
re greatly affected by implant porosity and composition than by additi
on of angiogenic enhancing agents. Further in vivo study, using other
potential angiogenesis-promoting agents as well as implants with diffe
rent pore characteristics, is warranted using this reliable and predic
table animal model.