Although rare, orbital osteomyelitis secondary to sinusitis can be dev
astating. Early, aggressive ophthalmologic surgical intervention, as w
ell as otorhinolaryngologic co-management, is necessary to obtain the
best outcomes. We present two cases of orbital osteomyelitis. One pati
ent remained infected with Pseudomonas meningitis even after extensive
sinus and orbital surgery, rapidly declined, and is now deceased. The
other patient, after multiple sinus procedures and a medial orbitotom
y, was placed on hyperbaric oxygen and is still undergoing treatment.