Serum alpha-interferon levels were analysed in 50 consecutive children
admitted with right iliac fossa pain. Serum alpha-interferon levels w
ere significantly raised in 33% of children without acute appendicitis
when compared to 5.7% of children with histologically proven acute ap
pendicitis and 9% of normal controls. This interesting phenomenon need
s further investigation. A larger series may show it to be of clinical
use in non-specific abdominal pain in childhood.