The unprotected left main stenosis still represents one of the contrai
ndications of PTCA; recently developed concepts using percutaneous byp
ass techniques have not changed this fact so far. However, following b
ypass grafting the procedure can be done with low risk and may improve
prognosis in case of later bypass occlusion. This study should clarif
y whether a higher rate of bypass occlusion is caused by postsurgical
left main PTCA. From October 1981 to January 1991 a left main stenosis
was dilated in 41 patients, 2 weeks to 12 years (mean 3.5 years) afte
r bypass grafting. To date, 17/65 venous bypass grafts were already oc
cluded, and 72.4% of the patients suffered from typical angina. In 34/
41 patients (82.9%) PTCA was successful, severe complications (death,
emergency surgery or myocardial infarction) did not occur and clinical
improvement was achieved in 80% of symptomatic patients. Four months
later, 26/34 patients (76.5%) had angiographic follow-up. Fifteen rest
enoses were found and a second PTCA was performed in 9/15. None of the
venous bypass grafts, open at the time of the first PTCA, was occlude
d at follow-up. In one case PTCA of the left main stenosis turned out
to be life-saving 7 years later because an occlusion of RCA- and LCX-b
ypasses occurred and the LAD graft showed a subtotal thrombosis. It is
concluded that PTCA of left main stenosis after bypass grafting is a
safe procedure and does not lead to a higher rate of venous bypass occ
lusions. A prognostic indication seems to be justified.