ASSOCIATION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE EXPRESSION WITH CELL MOTILITY AND METASTATIC POTENTIAL OF RAT PROSTATIC ADENOCARCINOMA

Authors
EPNER DE PARTIN AW SCHALKEN JA ISAACS JT COFFEY DS
Citation
De. Epner et al., ASSOCIATION OF GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE EXPRESSION WITH CELL MOTILITY AND METASTATIC POTENTIAL OF RAT PROSTATIC ADENOCARCINOMA, Cancer research, 53(9), 1993, pp. 1995-1997
Citations number
21
Categorie Soggetti
Oncology
Journal title
Cancer research → ACNP
ISSN journal
00085472
Volume
53
Issue
9
Year of publication
1993
Pages
1995 - 1997
Database
ISI
SICI code
0008-5472(1993)53:9<1995:AOGDEW>2.0.ZU;2-L
Abstract
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression is increas ed in Dunning R-3327 rat prostatic adenocarcinoma cell lines relative to normal rat ventral prostate tissue. GAPDH expression closely correl ates with cell motility of Dunning prostate cancer cell lines and accu rately distinguishes cell lines with high metastatic potential from th ose with low metastatic potential. Increased GAPDH expression in the c ancer cell lines is not simply related to increased growth rate, since rapidly proliferating normal prostate tissue did not exhibit elevated GAPDH expression.