PHARMACOKINETICS OF FLUVOXAMINE MALEATE AFTER INCREASING SINGLE ORAL DOSES IN HEALTHY-SUBJECTS

The pharmacokinetics of fluvoxamine after single oral administration o f 25, 50, and 100 mg fluvoxamine maleate was studied in a three-way cr oss-over study in 12 healthy male subjects. Fluvoxamine was administer ed orally in a solution. For dose-proportionality, AUC, and C(max)-dos e relationships were evaluated by linear regression. Plasma concentrat ions increased in a linear dose-dependent manner in the dose range bet ween 25 and 100 mg; t1/2 and T(max) showed no significant differences among treatments. Fluvoxamine was well tolerated.