A Bayesian belief network for grading prostatic lesions into eight pri
mary Gleason grades was developed and tested. The network employs 13 d
iagnostic clues, 8 based on tissue architectural features and 5 based
on nuclear features. For every diagnostic clue, three to five differen
t outcomes are specified by membership functions. The network works in
a robust fashion and attained agreement with consensus visual grading
in 241 of 256 microscopic fields.