We report three athletes with symptomatic isolated ganglion of the ant
erior cruciate ligament. The symptoms consisted of anteromedial knee p
ain, worse when changing direction while running, and on squatting. Al
l gave a history of repeated minor knee trauma without a single episod
e of serious injury. At day-case arthroscopy, a unilobulated cystic ma
ss arising from a clinically and arthroscopically intact anterior cruc
iate ligament was noted and removed in each case. No further intra- or
extra-articular knee lesion was seen. Histology revealed a cystic gan
glion in each case. With early physiotherapy, the patients could start
gentle training 3 wk after arthroscopy, and, at 6-month review, were
fully asymptomatic. A review of the literature shows that an isolated
ganglion arising from the anterior cruciate ligament is exceedingly ra
re, with only three such ganglia having been previously reported.