EFFECT OF AMIDOPYRINE IMMOBILIZED IN POLYVINYL-ALCOHOL ON MUTAGENICITY THE YEAST

Authors
KORZHENEVSKAYA MA MIKHEEV VS
Citation
Ma. Korzhenevskaya et Vs. Mikheev, EFFECT OF AMIDOPYRINE IMMOBILIZED IN POLYVINYL-ALCOHOL ON MUTAGENICITY THE YEAST, Genetika, 29(4), 1993, pp. 699-701
Citations number
4
Categorie Soggetti
Genetics & Heredity
Journal title
Genetika → ACNP
ISSN journal
00166758
Volume
29
Issue
4
Year of publication
1993
Pages
699 - 701
Database
ISI
SICI code
0016-6758(1993)29:4<699:EOAIIP>2.0.ZU;2-I
Abstract
Frequency of gene mutations was studied on the yeast Saccharomyces cer evisiae after treatment with amidopyrine (AP) and polyvinyl alcohol (P VA). PVA was found to have no mutagenic activity, whereas AP increased mutation frequency in dependence of drug concentration (15 and 30 mg/ ml) and the duration of cell treatment (4 and 24 hours). Immobilizatio n of AP in PVA led to decrease in drug mutagenicity.