ASSIGNMENT OF THE HUMAN UDP GLUCURONOSYLTRANSFERASE GENE (UGT1A1) TO CHROMOSOME REGION 2Q37

Authors
VANES HHG BOUT A LIU J ANDERSON L DUNCAN AMV BOSMA P ELFERINK RO JANSEN PLM CHOWDHURY JR SCHURR E
Citation
Hhg. Vanes et al., ASSIGNMENT OF THE HUMAN UDP GLUCURONOSYLTRANSFERASE GENE (UGT1A1) TO CHROMOSOME REGION 2Q37, Cytogenetics and cell genetics, 63(2), 1993, pp. 114-116
Citations number
22
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
63
Issue
2
Year of publication
1993
Pages
114 - 116
Database
ISI
SICI code
0301-0171(1993)63:2<114:AOTHUG>2.0.ZU;2-9
Abstract
UDP glucuronosyltransferases (UGTs) comprise a multigene family of dru g-metabolizing enzymes. The subfamily of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. I n man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein i soforms encoded by UGT1A1 originate by alternative splicing. In the pr esent study, we used the cDNA of UGT1A14, a bilirubin-conjugating iso form, to localize the UGT1A1 locus in the human genome. The UGT1A1 gen e was assigned by in situ hybridization to chromosome region 2q37.