SUPERPETT 3000 TIME-OF-FLIGHT PET TOMOGRAPH - OPTIMIZATION OF FACTORSAFFECTING QUANTITATION

Citation
W. Robeson et al., SUPERPETT 3000 TIME-OF-FLIGHT PET TOMOGRAPH - OPTIMIZATION OF FACTORSAFFECTING QUANTITATION, IEEE transactions on nuclear science, 40(2), 1993, pp. 135-142
Citations number
16
Categorie Soggetti
Nuclear Sciences & Tecnology","Engineering, Eletrical & Electronic
ISSN journal
00189499
Volume
40
Issue
2
Year of publication
1993
Pages
135 - 142
Database
ISI
SICI code
0018-9499(1993)40:2<135:S3TPT->2.0.ZU;2-R
Abstract
All PET tomographs are inherently quantitative imaging tools. However, to certify that the observed radioactivity in the organ of interest r epresents true underlying radioactivity concentration, requires an exp erimental/theoretical treatment of factors such as scatter, randoms, r econstruction parameters, recovery coefficients and cross-calibration procedure. We have used dual isotope experiments as an efficient metho d to check the overall tomograph performance and found that the inclus ion of a ''real-time'' calibration tube standard in the tomograph fiel d-of-view during scanning compensates for any temporal variation in th e machine sensitivity as well as provide a built-in dead time correcti on. Reconstruction parameters and recovery coefficients were optimized through phantom experiments. Last but not least, we have shown throug h human studies that results similar to other head and whole body scan ners have been achieved with the whole body Superpett 3000 time-of-fli ght tomograph at North Shore University Hospital.