M. Yasuda et al., PEPTIDE HISTIDINE METHIONINE IN CEREBROSPINAL-FLUID OF PATIENTS WITH SENILE DEMENTIA OF THE ALZHEIMER-TYPE, Japanese journal of psychiatry and neurology, 47(1), 1993, pp. 85-90
Immunoreactivities (IRs) of peptide histidine methionine (PHM) as well
as somatostatin and vasoactive intestinal peptide (VIP) in the cerebr
ospinal fluid (CSF) were measured in patients with senile dementia of
the Alzheimer type (SDAT) and age-matched control subjects. We found s
tatistically significant reductions in the PHM-IR and somatostatin-IR
levels in the CSF from patients with SDAT, as compared with those of t
he controls. However, the VIP-IR level in the CSF from SDAT was not di
fferent from that of the controls. These results suggest that selectiv
e degeneration of neurons containing somatostatin and PHM or the alter
ation in metabolism of PHM in the CSF might occur in SDAT.