CNS CHANGES IN DRPLA WITH DEMENTIA AND PERSONALITY CHANGES - CT, MR AND SPECT FINDINGS

CNS changes in a case of DRPLA associated with dementia and personalit y changes were observed by CT, MR and SPECT. Brain Cr and MR of the pa tient revealed progressive cortical atrophy which was recognized in pa rallel with the clinical course of the progression of dementia and per sonality changes. SPECT using I-123-iodoamphetamine (IMP) disclosed a diffuse low perfusion of the cerebral cortex, especially in the fronta l and temporal lobes. These findings suggest that the dementia and per sonality changes in this case might be concerned with a dysfunction of the cerebral cortex.