EFFECT OF ANTIGEN-SPECIFIC IMMUNOADSORPTION ON ANTIBODY KINETICS IN ARAT MODEL

Authors
ZEUNER RA BERESS R SCHROEDER JO EULER HH
Citation
Ra. Zeuner et al., EFFECT OF ANTIGEN-SPECIFIC IMMUNOADSORPTION ON ANTIBODY KINETICS IN ARAT MODEL, Biomaterials, artificial cells, and immobilization biotechnology, 21(2), 1993, pp. 199-211
Citations number
54
Categorie Soggetti
Engineering, Biomedical","Material Science
Journal title
Biomaterials, artificial cells, and immobilization biotechnology → ACNP
ISSN journal
10557172
Volume
21
Issue
2
Year of publication
1993
Pages
199 - 211
Database
ISI
SICI code
1055-7172(1993)21:2<199:EOAIOA>2.0.ZU;2-#
Abstract
The investigation of antibody kinetics following antigen-specific immu noadsorption in alkaline phosphatase immunized rats revealed significa ntly lower antibody levels than in untreated controls over a follow-up period of 6 weeks. A rebounding antibody synthesis as a result of spe cific depletion was not observed. Non-adsorption of specific antiidiot ypic antibodies may explain these findings.