REDUCED SENSITIVITY OF LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN MIGRAINE

Authors
KURITZKY A BENNET E HERING R EBSTEIN R
Citation
A. Kuritzky et al., REDUCED SENSITIVITY OF LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN MIGRAINE, Headache, 33(4), 1993, pp. 198-200
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Headache → ACNP
ISSN journal
00178748
Volume
33
Issue
4
Year of publication
1993
Pages
198 - 200
Database
ISI
SICI code
0017-8748(1993)33:4<198:RSOLBR>2.0.ZU;2-B
Abstract
Cyclic AMP(CAMP) accumulation induced by isoproterenol (IP) and forsko lin in intact lymphocytes was determined in 12 patients with migraine and 12 healthy controls. Our data showed that IP CAMP accumulation (8. 20 + 1.08 Pmol/mllion cells) was significantly (P = 0.033) lower than accumulation in the controls (14.39 + 2.44 Pmol/million cells). Forsko lin-induced CAMP did not differ in the two groups. These findings supp ort the association of migraine and a reduced lymphocyte beta-adrenerg ic receptor sensitivity. An alteration in lymphocyte beta-adrenergic r eceptor may reflect similar changes in central beta-adrenergic functio n and may be used as a probe to evaluate its activity.