THE INFLUENCE OF PROTECTING GROUPS ON LIPASE-CATALYZED TRANSESTERIFICATIONS - ENZYMATIC RESOLUTION OF RACEMIC CIS-1,3-CYCLOPENTANEDIOL DERIVATIVES

Authors
HENLY R ELIE CJJ BUSER HP RAMOS G MOSER HE
Citation
R. Henly et al., THE INFLUENCE OF PROTECTING GROUPS ON LIPASE-CATALYZED TRANSESTERIFICATIONS - ENZYMATIC RESOLUTION OF RACEMIC CIS-1,3-CYCLOPENTANEDIOL DERIVATIVES, Tetrahedron letters, 34(18), 1993, pp. 2923-2926
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
18
Year of publication
1993
Pages
2923 - 2926
Database
ISI
SICI code
0040-4039(1993)34:18<2923:TIOPGO>2.0.ZU;2-L
Abstract
The enzyme catalyzed acetylation of racemic cis-1,3-cyclopentanediol d erivatives (+/-)-2a-d in vinyl acetate is greatly influenced by the si ze of protecting groups at the additional trans-4-hydroxymethyl functi on. The highest regio- and enantioselectivities were obtained using th e diol substrate protected with the bulky triphenylmethyl (trityl) gro up.