N. Rubeiz et al., POSTTRANSFUSION GRAFT-VERSUS-HOST DISEASE IN 2 IMMUNOCOMPETENT PATIENTS, Journal of the American Academy of Dermatology, 28(5), 1993, pp. 862-865
Graft-versus-host disease may occur in certain immunocompromised patie
nts after a blood transfusion. The disease is characterized by fever,
a skin eruption, gastrointestinal disturbances, liver dysfunction, and
bone marrow aplasia. Two cases of fatal graft-versus-host disease are
reported. Both patients were immunocompetent and had received transfu
sions of nonirradiated blood from their children during surgery. The i
mportance of preventing this complication by irradiating blood product
s given to patients by their first-degree relatives is underscored.