We report the case of an alcoholic patient, 41 years old, with negativ
e results of serologic tests for human immunodeficiency virus (HIV) wi
th a perianal Buschke-Lowenstein tumor present for eight years and exc
eptionally large. The patient's cell-mediated immunity was evaluated b
y two functional tests: the Multitest IMC (Institut Merieux, Lyon) and
the dinitrochlorobenzene (DNCB) test. The patient neither responded t
o any Multitest antigens nor was sensitized by DNCB. We consider that
the immune shortage in this patient could influence the appearance of
the Buschke-Lowenstein tumor.