MOLECULAR DIAGNOSTICS FOR CYSTIC-FIBROSIS

There are many mutations that cause cystic fibrosis, however, only a f ew account for the majority of the cases. This article provides a revi ew of the molecular genetics of cystic fibrosis. A low cost technique for detection of the most common mutations is described. Emphasis is p laced on the appropriate applications and interpretations in the use o f molecular diagnostics for the diagnosis, carrier detection, and trea tment of cystic fibrosis. Emerging treatment possibilities, including gene therapy, are discussed.