PSYCHIATRIC-DIAGNOSIS AND THE SURGICAL OUTCOME OF PANCREAS TRANSPLANTATION IN PATIENTS WITH TYPE-I DIABETES-MELLITUS

To examine the role of psychiatric diagnosis in the surgical outcome o f pancreas transplantation, we studied candidates with type I diabetes mellitus. Eighty of 140 candidates underwent transplantation. Surviva l analysis found the extent of human leukocyte antigen-DR (HLA-DR) mat ching, two diagnoses, and patients' perceived support from first-degre e relatives to be related to duration of full-graft function. Lifetime diagnoses of tobacco use disorder (P = 0.029) and alcohol abuse/depen dence (P = 0.006) were associated with less favorable outcomes; percei ved support was associated with positive outcomes (P = 0.048). Subsequ ent analysis suggested that the four variables independently and direc tly affect outcome.